{"year":"2022","publication_status":"published","corporate_editor":["Dechema, GDCh, VDI, GVC"],"user_id":"216459","citation":{"short":"X.R. Steurer, D. Jakobs-Schönwandt, K. Forchhammer, A. Patel, in: Dechema, GDCh, VDI, GVC (Ed.), Special Issue: (Bio)Process Engineering – a Key to Sustainable Development: ProcessNet and DECHEMA‐BioTechNet Jahrestagungen 2022 Together with 13th ESBES Symposium, Wiley, 2022, p. 1263.","alphadin":"<span style=\"font-variant:small-caps;\">Steurer, Xenia Ricarda</span> ; <span style=\"font-variant:small-caps;\">Jakobs-Schönwandt, Desiree</span> ; <span style=\"font-variant:small-caps;\">Forchhammer, Karl</span> ; <span style=\"font-variant:small-caps;\">Patel, Anant</span>: Establishing production of a herbicidal sugar as sustainable alternative to glyphosate by a microbial chassis. In: <span style=\"font-variant:small-caps;\">Dechema, GDCh, VDI, GVC</span> (Hrsg.): <i>Special Issue: (Bio)Process Engineering – a Key to Sustainable Development: ProcessNet and DECHEMA‐BioTechNet Jahrestagungen 2022 together with 13th ESBES Symposium</i>, <i>Chemie Ingenieur Technik</i>. Bd. 94 : Wiley, 2022, S. 1263","ieee":"X. R. Steurer, D. Jakobs-Schönwandt, K. Forchhammer, and A. Patel, “Establishing production of a herbicidal sugar as sustainable alternative to glyphosate by a microbial chassis,” in <i>Special Issue: (Bio)Process Engineering – a Key to Sustainable Development: ProcessNet and DECHEMA‐BioTechNet Jahrestagungen 2022 together with 13th ESBES Symposium</i>, Aachen, 2022, vol. 94, no. 9, p. 1263.","apa":"Steurer, X. R., Jakobs-Schönwandt, D., Forchhammer, K., &#38; Patel, A. (2022). Establishing production of a herbicidal sugar as sustainable alternative to glyphosate by a microbial chassis. In Dechema, GDCh, VDI, GVC (Ed.), <i>Special Issue: (Bio)Process Engineering – a Key to Sustainable Development: ProcessNet and DECHEMA‐BioTechNet Jahrestagungen 2022 together with 13th ESBES Symposium</i> (Vol. 94, p. 1263). Aachen: Wiley. <a href=\"https://doi.org/10.1002/cite.202255311\">https://doi.org/10.1002/cite.202255311</a>","chicago":"Steurer, Xenia Ricarda, Desiree Jakobs-Schönwandt, Karl Forchhammer, and Anant Patel. “Establishing Production of a Herbicidal Sugar as Sustainable Alternative to Glyphosate by a Microbial Chassis.” In <i>Special Issue: (Bio)Process Engineering – a Key to Sustainable Development: ProcessNet and DECHEMA‐BioTechNet Jahrestagungen 2022 Together with 13th ESBES Symposium</i>, edited by Dechema, GDCh, VDI, GVC, 94:1263. Chemie Ingenieur Technik. Wiley, 2022. <a href=\"https://doi.org/10.1002/cite.202255311\">https://doi.org/10.1002/cite.202255311</a>.","bibtex":"@inproceedings{Steurer_Jakobs-Schönwandt_Forchhammer_Patel_2022, series={Chemie Ingenieur Technik}, title={Establishing production of a herbicidal sugar as sustainable alternative to glyphosate by a microbial chassis}, volume={94}, DOI={<a href=\"https://doi.org/10.1002/cite.202255311\">10.1002/cite.202255311</a>}, number={9}, booktitle={Special Issue: (Bio)Process Engineering – a Key to Sustainable Development: ProcessNet and DECHEMA‐BioTechNet Jahrestagungen 2022 together with 13th ESBES Symposium}, publisher={Wiley}, author={Steurer, Xenia Ricarda and Jakobs-Schönwandt, Desiree and Forchhammer, Karl and Patel, Anant}, editor={Dechema, GDCh, VDI, GVCEditor}, year={2022}, pages={1263}, collection={Chemie Ingenieur Technik} }","ama":"Steurer XR, Jakobs-Schönwandt D, Forchhammer K, Patel A. Establishing production of a herbicidal sugar as sustainable alternative to glyphosate by a microbial chassis. In: Dechema, GDCh, VDI, GVC, ed. <i>Special Issue: (Bio)Process Engineering – a Key to Sustainable Development: ProcessNet and DECHEMA‐BioTechNet Jahrestagungen 2022 Together with 13th ESBES Symposium</i>. Vol 94. Chemie Ingenieur Technik. Wiley; 2022:1263. doi:<a href=\"https://doi.org/10.1002/cite.202255311\">10.1002/cite.202255311</a>","mla":"Steurer, Xenia Ricarda, et al. “Establishing Production of a Herbicidal Sugar as Sustainable Alternative to Glyphosate by a Microbial Chassis.” <i>Special Issue: (Bio)Process Engineering – a Key to Sustainable Development: ProcessNet and DECHEMA‐BioTechNet Jahrestagungen 2022 Together with 13th ESBES Symposium</i>, edited by Dechema, GDCh, VDI, GVC, vol. 94, no. 9, Wiley, 2022, p. 1263, doi:<a href=\"https://doi.org/10.1002/cite.202255311\">10.1002/cite.202255311</a>."},"date_created":"2023-06-01T23:54:20Z","title":"Establishing production of a herbicidal sugar as sustainable alternative to glyphosate by a microbial chassis","publication":"Special Issue: (Bio)Process Engineering – a Key to Sustainable Development: ProcessNet and DECHEMA‐BioTechNet Jahrestagungen 2022 together with 13th ESBES Symposium","research_group":[{"name":"Bielefelder Institut für Angewandte Materialforschung (BIfAM)","_id":"af778127-b366-11ed-bde2-daed2b8eafee"}],"status":"public","_id":"3199","issue":"9","author":[{"id":"249921","first_name":"Xenia Ricarda","last_name":"Steurer","full_name":"Steurer, Xenia Ricarda"},{"full_name":"Jakobs-Schönwandt, Desiree","last_name":"Jakobs-Schönwandt","first_name":"Desiree"},{"first_name":"Karl","last_name":"Forchhammer","full_name":"Forchhammer, Karl"},{"id":"201870","first_name":"Anant","last_name":"Patel","full_name":"Patel, Anant"}],"publisher":"Wiley","doi":"10.1002/cite.202255311","volume":94,"publication_identifier":{"issn":["0009-286 X"]},"abstract":[{"lang":"eng","text":"Establishing production of a herbicidal sugar as sustainable alternative to glyphosate by a microbial chassis\r\nSteurer, X.1, Jakobs-Schönwandt, D.1, Forchhammer, K.2 and Patel, A.V.1\r\n 1University of Applied Sciences Bielefeld, Germany, 2University of Tübingen, Germany\r\nUntil now, glyphosate is widely applied to reduce weeds worldwide. Due to its negative impact on the environment, insects and humans [1] and likely prohibition in the EU until the end of 2023, an effective as well as ecologically acceptable alternative is urgently needed.\r\n7-deoxy-sedoheptulose (7dSh) might be such an alternative. This sugar is a novel herbicidal substance and was isolated from culture supernatants of Synechococcus elongatus [2]. Yet this cyanobacterium produces very low amounts of 7dSh in the stationary phase of cultivation [2] and is therefore not an adequate candidate for an industrial production. Unfortunately, chemoenzymatic synthesis of 7dSh has a low yield (20%) [2] and is not economically feasible because of the high costs of the substrate 5-deoxy-D-ribose. Therefore, we aim to provide a microbial chassis for large scale production of 7dSh. A promising option is 7dSh synthesis with Streptomyces setonensis as a natural producer strain [2]. First results indicate that production can be improved by mainly optimizing process control and culture conditions. To establish a continuous process in the bioreactor, cell immobilization will be explored.\r\nREFERENCES\r\n[1] Meftaul, I.M., Venkateswarlu, K., Dharmarajan, R. et al. Controversies over human health and ecological impacts of glyphosate: Is it to be banned in modern agriculture? Environ Pollut. 263(Pt A):114372 (2020).\r\n[2] Brilisauer, K., Rapp, J., Rath, P. et al. Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms. Nat Commun 10, 545 (2019).\r\n"}],"conference":{"location":"Aachen","name":"ProcessNet and DECHEMA‐BioTechNet Jahrestagungen 2022 together with 13th ESBES Symposium","end_date":"2022-09-15","start_date":"2022-09-12"},"series_title":"Chemie Ingenieur Technik","type":"conference","intvolume":"        94","language":[{"iso":"eng"}],"department":[{"_id":"103"}],"page":"1263","date_updated":"2023-06-02T11:43:01Z"}